Decreased expression of IL-4 Gene and Exploring of mutable lymphotoxin alpha (TNF-β) gene in Patients with Systemic Lupus Erythematosus

Authors

  • Wasnaa J. Mohammad College of Nursing, University of Baghdad , Baghdad, Iraq.
  • Noor. A. Ibrahim College of Nursing, University of Baghdad , Baghdad, Iraq.
  • Shahad F. Obeid College of Sciences, University of Baghdad , Baghdad, Iraq.

Rapid genetic system identification characterizes the complex illness known as systemic lupus erythematosus (SLE). The classic cytokine, IL-4, is known to stimulate the Th2 route of differentiation and to effectively inhibit the Th1 response. The pathogenesis of systemic lupus erythematosus (SLE) has been linked to immunological and genetic variables. Therefore, this study aimed to characterize the gene expression of IL-4 in peripheral blood mononuclear cells (PBMC) and explore potential links between the functional Interleukin-4 gene and SLE. Additionally, lymphotoxin alpha (LTA) is a key cytokine in the pathogenesis of SLE. In SLE, cytokines have a significant role in controlling lymphocyte function.

Keywords:

TNF-β gene, , peripheral blood mononuclear cells (PBMC), lymphotoxin alpha (LTA), TNF-cellular pathways, and systemic lupus erythematosus (SLE)

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Decreased expression of IL-4 Gene and Exploring of mutable lymphotoxin alpha (TNF-β) gene in Patients with Systemic Lupus Erythematosus. (2024). Journal Port Science Research, 7(1), 6-14. https://doi.org/10.36371/port.2024.1.2

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Decreased expression of IL-4 Gene and Exploring of mutable lymphotoxin alpha (TNF-β) gene in Patients with Systemic Lupus Erythematosus. (2024). Journal Port Science Research, 7(1), 6-14. https://doi.org/10.36371/port.2024.1.2