Design, Synthesis, In Silico Study and Anti-Inflammatory Evaluation of New Ketoprofen Thiourea Derivatives

Authors

  • Rafid M. Hashim College of Pharmacy, Uruk University, Baghdad, Iraq.
  • Yahya Yahya Zaki Farid College of Pharmacy, Uruk University, Baghdad, Iraq.

The In the current study, six new derivatives of ketoprofen thiourea were designed and synthesized In order to enhance COX-2 enzyme selectivity. The chemical structures of these derivatives were confirmed by spectral analysis. The anti-inflammatory activities of these derivatives was investigated insilico and in vivo. The results revealed that compound B4 were the most active.  The new derivatives also showed drug-likeness and gastric absorption as predicted by computational methods.  These results above indicated that the synthesized compounds deserve additional investigation as potential selective COX-2 inhibitors.

Keywords:

anti-inflammatory activity, ketoprofen, COX-2, paw edema, thiourea

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Design, Synthesis, In Silico Study and Anti-Inflammatory Evaluation of New Ketoprofen Thiourea Derivatives. (2024). Journal Port Science Research, 7(1), 69-76. https://doi.org/10.36371/port.2024.1.9

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Design, Synthesis, In Silico Study and Anti-Inflammatory Evaluation of New Ketoprofen Thiourea Derivatives. (2024). Journal Port Science Research, 7(1), 69-76. https://doi.org/10.36371/port.2024.1.9