FREQUENCY OF HEPATITIS C VIRUS INFECTION AMONG BETA-THALASSEMIA PATIENTS IN BAGHDAD CITY, IRAQ

المؤلفون

  • Ali Muwafaq Yaqoob Ministry of Health, Iraq
  • Falah Salim Manhal Uruk University

Patients with thalassemia major are at high risk of Hepatitis C virus (HCV) due to the blood transfusion from donors infected by HCV. The purpose of this study was to study the correlation between some hematological parameters and liver function tests with viral hepatitis and to evaluate the ELISA and RT- PCR techniques for the diagnosis of HCV in thalassaemic patients. Blood samples from eighty patients with ß-thalassemia were subjected to the following tests: PCV, Hb concentration, liver function tests (GPT, GOT, Alkaline phosphatase). Serum samples from all patients were tested for antibodies to hepatitis C virus using ELISA test and for HCV RNA by the real time polymerase chain reaction (RT-PCR). It was shown that 67.5% of study patients were detected with a range of PCV 15-20%, whereas 100% of patients were detected with a range of Hb (5-9 g/dL). In addition, 98.8% of patients were detected with elevated liver enzymes. It was shown that 100% of patients revealed with positive ELISA anti-HCV antibodies in their serum specimens. Positive RT-PCR assay was detected in 86% of study patients. ELISA test was revealed with 14% false positive results. Thalassemia patients should be aware of the risks of viral infection during their blood transfusions, and those with chronic infections should beware of transmitting the infection to uninfected individuals.Thalassemia

الكلمات المفتاحية:

Thalassemia، HCV، Liver function tests، ELISA، PCR

[1] Amin, S., Jalal, S., Ali, K., Rasool, L., Osman, T., Ali, O., & M-Saeed, A. (2020). Molecular characterization and disease-related morbidities of β-thalassemia patients from the northeastern part of Iraq. International Journal of General Medicine, 13, 1453–1467. https://doi.org/10.2147/IJGM.S277947.

[2] Galanello, R., & Origa, R. (2010). Beta-thalassemia. Orphanet Journal of Rare Diseases. https://doi.org/10.1186/1750-1172-5-11.

[3] Houghton, M. (2009, November). The long and winding road leading to the identification of the hepatitis C virus. Journal of Hepatology. https://doi.org/10.1016/j.jhep.2009.08.004

[4] Akhtar, S., Nasir, J. A., & Hinde, A. (2020, April 29). The prevalence of hepatitis C virus infection in β-thalassemia patients in Pakistan: A systematic review and meta-analysis. BMC Public Health. BioMed Central Ltd. https://doi.org/10.1186/s12889-020-8414-5.

[5] Najim, O., & Hassan, M. (2018). Prevalence of hepatitis C virus seropositivity among multitransfused patients with hereditary anemias in Basra, Iraq. Iraqi Journal of Hematology, 7(1), 39. https://doi.org/10.4103/ijh.ijh_41_17

[6] Ramadhan, A. A. (2018). Prevalence of hepatitis b and hepatitis c virus infections at premarital screening program in Duhok, Iraq. Duhok Medical Journal, 12(1), 13–23. https://doi.org/10.31386/dmj.uod.18.12.1.2

[7] Jalal, Sana D. (2010). Prevalence and hematologic profile of δβ0-thalassemia trait in Sulaimani province Iraqi Kurdistan. Duhok Medical Journal،Vol. 4, no. 2, pp.84-91. https://search.emarefa.net/detail/BIM-722826.

[8] Muncie, H. L., & Campbell, J. S. (2009, August 15). Alpha and beta thalassemia. American Family Physician. American Academy of Family Physicians.

[9] Karim, F., Ismail, M., Hasan, A. M., & Shekhar, H. U. (2016). Hematological and biochemical status of Beta thalassemia major patients in Bangladesh: A comparative analysis. International Journal of Hematology-Oncology and Stem Cell Research, 10(1), 224–229.

[10] Ameli, M., Besharati, S., Nemati, K., & Zamani, F. (2008). Relationship between elevated liver enzyme with iron overload and viral hepatitis in thalassemia major patients in Northern Iran. Saudi Medical Journal, 29(11), 1611–1615.

[11] Ansar, M. M., & Kooloobandi, A. (2002). Prevalence of hepatitis C virus infection in thalassemia and haemodialysis patients in north Iran-Rasht. Journal of Viral Hepatitis, 9(5), 390–392. https://doi.org/10.1046/j.1365-2893.2002.00368.x

[12] Boroujerdnia, M. G., Assarehzadegan, M. A., Zandian, K. M., & Rodan, M. H. (2009). Prevalence of hepatitis-C virus (HCV) among thalassemia patients in Khuzestan province, southwest Iran. Pakistan Journal of Medical Sciences, 25(1), 113–117.

[13] Hussein, N. R., Sharaf, H. A., & Mahdi, S. (2019). The Prevalence of Hepatitis C Virus Infection in Pregnant Women in Duhok City, Kurdistan Region of Iraq: A Brief Report. Women’s Health Bulletin, In Press (In Press). https://doi.org/10.5812/whb.91494.

[14] Al-Kubaisy, W. A., Al-Naib, K. T., & Habib, M. (2006). Seroprevalence of hepatitis C virus specific antibodies among Iraqi children with thalassaemia. Eastern Mediterranean Health Journal, 12(1–2), 204–210.

[15] Di Marco, V., Capra, M., Angelucci, E., Borgna-Pignatti, C., Telfer, P., Harmatz, P., Maggio, A. (2010). Management of chronic viral hepatitis in patients with thalassemia: Recommendations from an international panel. Blood, 116(16), 2875–2883. https://doi.org/10.1182/blood-2009-11-248724.

FREQUENCY OF HEPATITIS C VIRUS INFECTION AMONG BETA-THALASSEMIA PATIENTS IN BAGHDAD CITY, IRAQ . (2022). Journal Port Science Research, 5(1), 21-28. https://doi.org/10.36371/port.2022.1.3

الرخصة

الحقوق الفكرية (c) 2022 Journal Port Science Research

Creative Commons License

هذا العمل مرخص بموجب Creative Commons Attribution-ShareAlike 4.0 International License.

كيفية الاقتباس

FREQUENCY OF HEPATITIS C VIRUS INFECTION AMONG BETA-THALASSEMIA PATIENTS IN BAGHDAD CITY, IRAQ . (2022). Journal Port Science Research, 5(1), 21-28. https://doi.org/10.36371/port.2022.1.3

الأعمال الأكثر قراءة لنفس المؤلف/المؤلفين